Daniel James was ruled after suffering a dip into their victory over Leicester.
The 21-year-old has created five appearances and scored three goals for United this year.
The midfielder, who arrived for #15m at the summertime, failed to train with the group on Wednesday ahead of their Team L clash.
Prior to Thursday’s tie, United boss Ole Gunnar Solskjaer confirmed:”Yeah, he (James) obtained a knock Leicester so he won’t be accessible.”
Luke Shaw (hamstring), Paul Pogba (foot ) and Anthony Martial (thigh) will also be absent ahead of the start of United’s Europa League campaign.
Meanwhile, the Solskjaer are available for selection and confirmed that Jesse Lingard and Diogo Dalot have returned into fitness.
More to follow…

Read more: footballleagueworld.com